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LTYC’s school based arts programs strengthen and supplement arts instruction in persistently low-performing schools. They offer students intense, rigorous training in the performing and creative arts at a pre-professional level.

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Then we obtain c i via

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c i = ( u ) 1 { β ( u g ) ( f ( k i ) z ) f ( k i ) z ϕ ( d z ) }

where ( u ) 1 is the inverse function of u

Finally, for each c i we set y i = c i + k i

It is clear that each ( y i , c i ) pair constructed in this manner satisfies Saint Laurent Cloth Flats E7IRY

With the points { y i , c i } in hand, we can reconstruct K g via approximation as before

The name EGM comes from the fact that the grid { y i } is determined endogenously

endogenously

Let’s implement this version of the Coleman operator and see how it performs

Here’s an implementation of K using EGM as described above

Note the lack of any root finding algorithm

We’ll also run our original implementation, which uses an exogenous grid and requires root finding, so we can perform some comparisons

Let’s test out the code above on some example parameterizations, after the following imports

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, let’s start by testing our method with the log-linear benchmark

View larger version:
FIG. 1.

Longitudinal functional analysis of HCMV-specific T cells in HLA class I-matched SOT recipients using IFN-γ ELISPOT assays and peptide epitopes from HCMV antigens (Table Alma en Pena Wedge sandals gold oporto 89NuRD7E
). Data from an individual recipient are presented in each panel. Data from individuals with no evidence of viral recrudescence are presented in panels A to E, those from individuals with asymptomatic recrudescence are presented in panels F to J, and those from individuals with symptomatic recrudescence are presented in panels K to O. Data presented in panels A to E, K, L, and N are based on SOT patients who received heart and/or lung transplants, while data in panels F to J, M, and O are based on renal transplant recipients. Gray-shaded areas in panels K to O indicate the time period when clinically active HCMV disease was diagnosed and the patient was being treated with antiviral medication (Table 2 ). Patients B, D, and E received antiviral prophylaxis based on oral ganciclovir. The results are expressed as spot-forming cells (SFC) per 10 CD3/CD8 T cells. Also shown in panels F to O is the HCMV load in peripheral blood of these patients as HCMV copies/10 PBMC. Blood sample collection time points (weeks) for each of the donors are indicated on the axis.

View larger version:
FIG. 2.

Ex vivo enumeration of HCMV-specific CD8 T cells using MHC-peptide multimers. PBMC from SOT recipients were costained with anti-human CD8 tricolor-labeled antibody and phycoerythrin (PE)-labeled MHC-peptide tetramers/pentamers. The fluorescence intensity was assessed with a FACSCalibur, and data were analyzed using Cellquest software. Representative data plots for three different HCMV epitopes, NLV (HLA A2 restricted), VTE (HLA A1 restricted), and TPR (HLA B7 restricted), are shown in panel A. Panel B shows percentages of MHC-peptide multimer-positive CD8 T cells in samples from individuals with no evidence of viral recrudescence, with asymptomatic recrudescence, and with symptomatic recrudescence. Panel C shows the phenotypic analysis of HCMV-specific T cells in these individuals. HCMV-specific T cells were costained with anti-human CD38 antibody. Data presented in panels B and C are based on all the blood samples collected at different time points as indicated in Fig. Call it Spring Alelawiel Sneakers FPxXj8
. values were calculated using the nonparametric Mann-Whitney test. ns, not significant.

View this table:
TABLE 1.

List of HLA class I-restricted HCMV epitopes used in this study

View this table:
TABLE 2.

Clinical syndrome in active HCMV disease

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This work was supported by research funding from the Prince Charles Hospital Foundation, Cooperative Research Centre for Vaccine Technology, and the National Health and Medical Research Council (Australia), James S. McDonnell Foundation 21st Century Research Award/Studying Complex Systems, Cooperative Research Centre for Vaccine Technology. R.K. is supported by a Principal Research Fellowship from the National Health and Medical Research Council. M.P.D. is a Sylvia and Charles Viertel Senior Medical Research Fellow.

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Remaining Objective Is Hard, But the Best Leaders Figure Out How to Do It
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Executive Summary

There is no single leadership trait that guarantees success in any profession, but there is one that many of the best leaders share: a fierce commitment to objectivity. And yet it’s often not easy for leaders to remain objective. Perhaps nowhere is this struggle more clear, or the stakes higher, than in the intelligence community, where leaders are charged with providing balanced, fact-based advice to the President. It’s never easy to deliver bad news or appear critical of a policy, but the best intelligence leaders know that it’s their job to tell the White House the unvarnished truth— not to make policy, but to give the Executive Branch the data it needs to make those policy decisions.Regardless of the work you do, prize your objectivity, and work every day to preserve it.

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There is no single leadership trait that guarantees success in any profession, but there is, based on my experience, one that many of the best leaders share: a fierce commitment to objectivity. And yet I realize it’s often not easy for leaders to remain objective.

In my nearly three-decade career in the intelligence community, I have worked for and with11 Directors of CIA and all five Directors of National Intelligence. Each has brought their own personality and skill set to the job, and each in their time has faced their own set of challenges, from deeply contentious relationships with the White House and Congress to unforeseen terrorist attacks on the homeland and U.S. diplomatic facilities overseas. I think each would agree that leading in the intelligence community is a daily exercise in crisis management, whether at the helm of CIA with its global analytic and operational responsibilities, or at the Office of the Director of National Intelligence with its oversight responsibilities for the entire intelligence community.

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